| There are several kinds of glaucoma.
The two major types are primary open-angle glaucoma (POAG)
and angle-closure or narrow-angle glaucoma. There are also
several secondary types.
- Primary open-angle glaucoma (POAG) is the
most common form of glaucoma, and it afflicts about 2.2
million people in the U.S. It is the most common form of
glaucoma in Caucasians and those of African descent. With
POAG, the entrances to the drainage canals usually remain
open, but the disease develops as the canals that drain
fluid become clogged, which causes inner eye pressure to
rise. POAG typically has no symptoms and can develop over
several years with no loss of vision. It gradually reduces
vision if it is not diagnosed and treated. If diagnosed
early, it usually responds well to treatment.
- Angle-closure glaucoma may develop gradually
or quickly. If it develops suddenly, it may be called acute
glaucoma or narrow-angle glaucoma, which is a medical emergency
requiring immediate attention. This form of glaucoma is
more common in people of Chinese ancestry. In the U.S.,
it is less frequent than POAG and very different from it
in that the eye pressure usually increases quickly. With
angle-closure glaucoma, the angle between the iris and cornea
becomes narrow or obstructed so that aqueous pressure builds
to levels high enough to damage the optic nerve before draining.
This condition tends to occur in far-sighted eyes, which
may be slightly smaller than others and have more crowded
internal structures. Under some circumstances, such as when
one enters a dark room, the pupil (the opening in the central
part of the iris) dilates (opens) causing the outer edge
of the iris to gather and fold, blocking the entrance to
the drainage canals. Certain medications, including some
over the counter cold and sinus remedies may provoke such
a blockage. When purchasing drugs, always be sure to discuss
side effects with your pharmacist.
Surgery (typically laser therapy) to remove a small portion
of the outer edge of the iris is usually performed to treat
angle-closure glaucoma. The removal of the excess tissue
prevents blockage of the angle, allowing normal fluid drainage.
Angle-closure glaucoma may lead to symptoms such as nausea,
headache, pain, blurry vision, and rainbow-like colors around
lights at night.
- Normal-tension glaucoma, also known
as low-tension glaucoma, is diagnosed in patients who have
two of the three main signs of glaucoma: loss of optic nerve
head tissue or cupping and visual field loss without high
intraocular pressure. People at higher risk for this form
of glaucoma are those with a family history of this condition,
those who have a history of migraine headache and poor circulation,
and people of Japanese ancestry.
- Secondary glaucoma is a term for
a variety of other forms of glaucoma. Typically, it occurs
when the flow of aqueous from the eye is impaired. It can
result from a disorder present locally in the eye such as
inflammation or a tumor, an eye injury, advanced cataracts
or diabetes, and certain drugs such as steroids.
Treatment for secondary forms of glaucoma depends on the
precipitating cause. Once the underlying cause of increased
intraocular pressure is corrected or cured (e.g., removal
of a tumor), the pressure may return to normal and continued
treatment with medication may not be needed. However, if
optic nerve damage occurs, visual field loss will remain.
- Pseudoexfoliation glaucoma is associated
with the formation of flakes of granular material at the
edges of the pupil and throughout the inner surface of the
front part of the eye. It is the most common identifiable
form of secondary open-angle glaucoma worldwide. The glaucoma
develops as the aqueous picks up flakes of material as it
flows through the front part of the eye and deposits them
in the trabecular meshwork tissue and drainage canals. Over
time, these deposits build up and block drainage of aqueous,
which increases intraocular pressure. This condition is
treated with drugs and surgery. The glaucoma associated
with this condition usually develops in people in their
70s and 80s.
- Pigmentary glaucoma is a form of
open-angle glaucoma. It develops as the aqueous picks up
pigment granules that break off the back of the iris and
deposits them in the meshwork tissue and drainage canals.
The deposits build up and block drainage of aqueous, which
increases intraocular pressure. This condition is treated
with drugs and surgery. It is usually seen in young and
middle-aged people who are near-sighted. It is slightly
more prevalent in men than in women.
- Primary congenital glaucoma affects
infants. Most cases are detected during the first few months
of life. Congenital glaucoma occurs when the trabecular
meshwork does not fully open in the developing fetus, causing
drainage to be impeded and fluid pressure to build. The
elasticity of an infant’s eye, coupled with increased
pressure, may cause the eye to enlarge and stretch. The
stretching can cause the cornea to cloud. If a child’s
eye is cloudy, white, hazy, or enlarged, a pediatrician
or ophthalmologist should be contacted immediately.
Cataracts and glaucoma are two eye diseases
often associated with advancing age. Many older people have
both conditions. With relatively rare exceptions, cataracts
do not cause glaucoma and glaucoma does not cause cataracts.
The frequency of both conditions occurring in older people
underscores the need for regular eye examinations.
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